Shikari® Anti-Ocrelizumab ELISA Kit

$1,570.00

The Shikari® Anti-Ocrelizumab ELISA Kit is intended for the quantitative determination of antibodies to of Ocrelizumab in serum and plasma with confirmation. The Shikari® Anti-Ocrelizumab ELISA Kit is for Research Use Only and not for diagnostic procedures.

Anti-ocrelizumab antibodies are anti-drug antibodies (ADAs) that may be produced by the immune system in response to treatment with ocrelizumab, a CD20-targeting monoclonal antibody used for multiple sclerosis (MS). These antibodies can potentially alter the drug’s pharmacokinetic and pharmacodynamic profiles, especially if they are neutralizing antibodies (NAbs), which may inhibit the drug’s ability to bind CD20 and deplete B cells. While ocrelizumab is engineered to be less immunogenic than earlier anti-CD20 agents like rituximab, the risk of immunogenicity still exists, particularly with repeated infusions or individual patient variability.

In research and clinical settings, monitoring anti-ocrelizumab antibody formation can provide crucial insights into patient response, drug efficacy, and potential adverse effects. Detecting these antibodies helps assess the likelihood of reduced therapeutic benefit or increased risk of infusion reactions. This is especially important for therapeutic drug monitoring (TDM), where regular measurement of drug levels and ADA presence supports individualized treatment decisions and improves long-term patient management.

Anti-ocrelizumab antibody testing is also valuable in biosimilar development and regulatory evaluation to ensure comparable immunogenicity profiles to reference products. Additionally, ADA surveillance aids in understanding immune-related mechanisms that might influence disease progression or therapeutic outcomes, particularly in chronic conditions like MS where long-term immunotherapy is essential.

This product is manufactured in Turkey by Matriks Biotek.

Size 1 x 96 Well
Sensitivity 0.5 µg/mL
Dynamic Range 10-300 ng/mL
Incubation Time 140 minutes
Sample Type Serum, Plasma
Immunogen
Source Species
Specificity
Expression System
Clone
Group
Alpha Chain
Beta Chain
Peptide
Peptide Source
Format
Buffer
Concentration
Storage 2-8°C
Alternative Names Anti-ocrelizumab antibodies, Ocrelizumab-directed ADAs, Ocrelizumab-reactive immunoglobulins, Anti-CD20 biologic antibodies, Ocrelizumab-binding antibodies, Human anti-ocrelizumab antibodies, Anti-ocrelizumab immune response markers, Therapeutic antibody-induced antibodies to ocrelizumab, Ocrelizumab-specific IgG antibodies, Ocrelizumab-targeted anti-drug antibodies.
Instructions For Use https://eaglebio.com/wp-content/uploads/2025/06/OCR-QNS-OCR_shikari-anti-ocrelizumab-elisa-instructions-for-use-1.pdf
MSDS https://eaglebio.com/wp-content/uploads/2025/06/OCR-QNS-OCR_shikari-anti-ocrelizumab-elisa-sds.pdf

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