Rheumatoid factor (RF) is an autoantibody, most commonly of the IgG or IgM class, that targets the Fc portion of immunoglobulin G. RF is produced by B cells and is associated with abnormal immune activation, contributing to the formation of immune complexes that can deposit in joints and tissues, driving inflammation and tissue damage. While RF can be present in healthy individuals, elevated levels are commonly associated with autoimmune diseases, particularly rheumatoid arthritis (RA), and may also be detected in other conditions such as Sjögren’s syndrome, chronic infections, and certain chronic inflammatory disorders.
The RF IgG ELISA is an immunoassay designed to specifically quantify IgG-class rheumatoid factor in serum or plasma. In research contexts, this assay is used to study the immunopathogenesis of autoimmune diseases, explore correlations between RF levels and disease activity, and evaluate the effects of experimental therapies on autoantibody production. It is also employed in basic immunology studies to understand B cell activation, tolerance breakdown, and the role of autoantibodies in systemic inflammation.
Clinically, RF IgG ELISA is used as a diagnostic and prognostic tool for autoimmune disorders, particularly rheumatoid arthritis. Elevated RF IgG levels can support disease diagnosis, help stratify patients by disease severity, and monitor responses to immunomodulatory therapies. Additionally, measuring RF can aid in distinguishing autoimmune-related joint inflammation from other causes, guiding clinicians in treatment decisions and long-term disease management.
This product is manufactured in Germany by Medipan GmbH.
| Size | 1 x 96 Well |
| Sensitivity | 3 U/mL |
| Dynamic Range | 3 -300 U/mL |
| Incubation Time | 2 hours 30 minutes |
| Sample Type | Serum |
| Storage | 2-8°C |
| Alternative Names | RF IgG antibody, IgG rheumatoid factor, and immunoglobulin G rheumatoid factor. |
