The Anti–Endothelin Receptor A (ETA) Antibodies IgG (Rat) ELISA Kit is designed to detect and quantify IgG autoantibodies targeting the Endothelin Receptor A (ETA) in rat samples. ETA is a G-protein–coupled receptor that mediates the vasoconstrictive and proliferative effects of endothelin-1, playing a critical role in vascular tone, blood pressure regulation, and organ perfusion. Autoantibodies against ETA have been associated with cardiovascular dysfunction, autoimmune vascular disorders, and inflammatory conditions, making their detection crucial in preclinical research.
In this ELISA, microplate wells are coated with recombinant or synthetic ETA antigens to specifically capture ETA-directed IgG antibodies from rat serum or plasma. Following antigen–antibody binding, an enzyme-linked secondary antibody produces a measurable colorimetric signal proportional to the concentration of anti-ETA IgG. This provides a sensitive, specific, and reproducible method for evaluating autoantibody levels.
Applications of the Anti–Endothelin Receptor A (ETA) Antibodies IgG (Rat) ELISA Kit include studying autoimmune or immune-mediated vascular dysfunction, investigating antibody contributions to hypertension or pulmonary arterial disease in rat models, and evaluating the immunogenicity of ETA-targeted therapeutics. Quantifying these antibodies helps researchers understand immune-mediated modulation of the endothelin system and supports the development of potential interventions in cardiovascular and renal disease models.
This product is manufactured in Germany by CellTrend GmbH.
| Size | 1 x 96 Well |
| Sensitivity | Cut-off |
| Dynamic Range | 1.25 -40 U/mL |
| Incubation Time | 3 hours 30 minutes |
| Sample Type | Serum, Plasma |
| Storage | 2-8°C |
| Alternative Names | rat ETA receptor–specific IgG, rat endothelin A receptor–targeting IgG antibodies, anti-endothelin A receptor IgG (rat), rat ETA receptor–reactive IgG, or rat endothelin receptor A–directed IgG antibodies |
