The Rat Anti–Angiotensin II Receptor 1 (AT1) IgM Antibody ELISA Kit is designed to detect and quantify IgM antibodies directed against the Angiotensin II Type 1 Receptor (AT1R) in rat samples. AT1R, a key G-protein–coupled receptor in the renin–angiotensin system, regulates blood pressure, vascular tone, and fluid balance. IgM-class autoantibodies against AT1R are often indicative of early or acute immune responses and can provide important insights into the pathophysiology of autoimmune, cardiovascular, and inflammatory conditions in preclinical rat models.
In this ELISA, microplate wells are coated with recombinant or synthetic AT1R antigens to specifically capture AT1R-targeting IgM antibodies from rat serum or plasma. Following antigen–antibody binding, an enzyme-linked secondary antibody generates a colorimetric signal proportional to the level of anti-AT1R IgM present. This provides a sensitive, specific, and reproducible method suitable for quantifying early immune responses in experimental studies.
Applications of the Rat Anti–Angiotensin II Receptor 1 IgM Antibody ELISA Kit include investigating immune-mediated hypertension, vascular inflammation, or transplant rejection in rat models, monitoring acute or primary antibody responses, and evaluating the role of AT1R-directed IgM in disease progression. Measuring these antibodies helps researchers understand the early phases of autoantibody-mediated modulation of the renin–angiotensin system and supports preclinical therapeutic studies.
This product is manufactured in Germany by CellTrend GmbH.
| Size | 1 x 96 Well |
| Sensitivity | Cut-off |
| Dynamic Range | 1.25 -40 U/mL |
| Incubation Time | 3 hours 30 minutes |
| Sample Type | Serum, Plasma |
| Storage | 2-8°C |
| Alternative Names | rat AT1 receptor–specific IgM, rat angiotensin II receptor 1–targeting IgM antibody, anti-AT1 IgM (rat), rat AT1R–reactive IgM, or rat angiotensin II receptor 1–directed IgM antibody |
