Nitrotyrosin (EDTA-Plasma) ELISA Kit

$1,250.00

The Nitrotyrosin (EDTA-Plasma) ELISA Kit is intended for the quantitative determination of protein-bound nitrotyrosine in human EDTA-plasma, serum and dried blood spots. For research use only. Not for use in diagnostic procedures.

SKU: KR7829 Category: Tags: , , ,

Nitrotyrosine is a post-translationally modified form of the amino acid tyrosine, formed through the nitration of its phenolic ring by reactive nitrogen species, particularly peroxynitrite (ONOO⁻), a byproduct of nitric oxide (•NO) and superoxide (•O₂⁻) interactions. This stable modification is considered a hallmark of nitrosative stress and serves as a surrogate marker for peroxynitrite generation. Elevated nitrotyrosine levels are associated with numerous pathological conditions driven by inflammation and oxidative stress, including cardiovascular diseases such as atherosclerosis, myocardial infarction, and diabetic vasculopathy, as well as various neurodegenerative disorders like Alzheimer’s, Parkinson’s, and multiple sclerosis.

In a clinical and research context, nitrotyrosine serves as a valuable biomarker for assessing the degree of nitrosative and oxidative stress. Its quantification can be used to monitor disease progression, evaluate the effectiveness of therapeutic interventions, and study the pathophysiological mechanisms underlying inflammatory conditions. Levels of nitrotyrosine have been shown to decrease with successful treatment of the associated diseases, reinforcing its utility in disease monitoring. Due to its biochemical stability and strong correlation with peroxynitrite production, nitrotyrosine is frequently employed in both basic and translational research investigating oxidative injury and systemic inflammation.

This product is manufactured in Germany by Immundiagnostik AG.

Size 1 x 96 Well
Sensitivity 1.437 nmol/L
Dynamic Range 4.9-400 nM
Incubation Time 2.25 hours
Sample Type EDTA Plasma, Serum, Dried Blood Spots
Immunogen
Source Species
Specificity
Expression System
Clone
Group
Alpha Chain
Beta Chain
Peptide
Peptide Source
Format
Buffer
Concentration
Storage 2-8°C
Alternative Names Nitrotyrosine, 3-nitrotyrosine, o-nitrotyrosine, 3-nitro-L-tyrosine, nitrated tyrosine, tyrosine nitro derivative, peroxynitrite-modified tyrosine, NO₂-tyrosine, nitrated phenolic amino acid, oxidative stress marker tyrosine.
Instructions For Use https://eaglebio.com/wp-content/uploads/2025/05/KR7829-Nitrotyrosin-EDTA-Plasma-ELISA-Kit-1.pdf
MSDS https://eaglebio.com/wp-content/uploads/2019/06/KR7829-nitrotyrosine-edta-plasma-elisa-assay-kit-MSDS.pdf

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