Mouse Tissue-type Plasminogen Activator (tPA) is a serine protease that plays a central role in the fibrinolytic system by converting plasminogen into plasmin, thereby facilitating the breakdown of blood clots. In mice, tPA is expressed primarily in endothelial cells and is involved not only in fibrinolysis but also in processes such as tissue remodeling, wound healing, and neuronal plasticity. Measuring total tPA antigen provides insight into both active and inactive forms of the protein, making it a valuable biomarker for studying the regulation of fibrinolytic activity and related physiological pathways.
The Mouse tPA Total Antigen ELISA allows for precise quantification of tPA levels in plasma, serum, or tissue extracts. In research settings, this assay is widely used to investigate the mechanisms of thrombosis, stroke, cardiovascular disease, and tissue injury. It also serves as a tool for studying the effects of genetic modifications, pharmacological interventions, or experimental treatments on tPA expression and regulation in mouse models, providing critical data for translational studies.
While primarily used in preclinical research, insights gained from tPA measurements in mice can inform clinical understanding of fibrinolytic disorders and therapeutic approaches in humans. For instance, studying tPA regulation in animal models helps evaluate potential drug candidates aimed at enhancing fibrinolysis in thrombotic diseases or modulating tPA activity in neurological injury. The assay thus contributes to both mechanistic studies and the development of targeted therapies.
This product is manufactured in by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 0.1 ng/mL |
| Dynamic Range | 0.1 – 50 ng/mL |
| Incubation Time | 2 hours |
| Sample Type | Biological Fluids |
| Alternative Names | PLAT, PLAT1, Tissue Plasminogen Activator, and Serine Protease tPA. |
