Mouse Tissue-type Plasminogen Activator (tPA) is a serine protease that plays a central role in the fibrinolytic system by converting plasminogen into plasmin, which degrades fibrin clots. It is primarily expressed in endothelial cells and is tightly regulated under physiological conditions to maintain hemostatic balance. Beyond its role in fibrinolysis, tPA is involved in tissue remodeling, neuronal plasticity, and inflammatory responses, making it a critical biomarker for studying both cardiovascular and neurological processes in mouse models.
The Mouse tPA Active ELISA is a sensitive assay that specifically measures the enzymatically active form of tPA in mouse plasma, serum, or tissue extracts. In research settings, this ELISA is widely used to investigate the regulation of fibrinolysis, the effects of genetic modifications, or pharmacological interventions on tPA activity. It also allows researchers to study pathological conditions such as thrombosis, stroke, or tissue injury where altered tPA activity may contribute to disease progression.
Although primarily a research tool, data from Mouse tPA Active ELISAs can provide insights relevant to clinical studies, especially when using mouse models to test novel therapeutics targeting the fibrinolytic pathway. By quantifying active tPA, researchers can evaluate treatment efficacy, monitor disease progression, and better understand mechanisms underlying disorders related to clot formation and degradation, informing translational studies for human health.
This product is manufactured in by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 0.1 ng/mL |
| Dynamic Range | 0.1 – 50 ng/mL |
| Incubation Time | 2 hours 30 minutes |
| Sample Type | Biological Fluids |
| Alternative Names | PLAT, tissue plasminogen activator, and serine protease tPA. |
