Mouse/Rat 25-OH Vitamin D ELISA Kit

Vitamin D, primarily measured as 25-hydroxyvitamin D [25(OH)D] in serum, is a crucial biomarker reflecting an individual’s vitamin D status. It is synthesized in the skin upon exposure to ultraviolet B (UVB) rays and undergoes hydroxylation in the liver and kidneys to form its active metabolites. These metabolites play vital roles in calcium and phosphate homeostasis, bone metabolism, and modulating immune responses. Deficiencies in vitamin D are associated with various health issues, including osteoporosis, cardiovascular diseases, autoimmune disorders, and certain cancers. Therefore, monitoring 25(OH)D levels is essential for assessing and managing these conditions.

In clinical and research settings, 25(OH)D serves as a standard biomarker for evaluating vitamin D status and its implications in health and disease. In research, its role is explored in various contexts, including its potential as a prognostic biomarker in diseases like COVID-19, Alzheimer’s, and Parkinson’s disease. For instance, studies have shown associations between low vitamin D levels and increased risks of these diseases, highlighting its potential utility in clinical decision-making and patient management.

Additionally, vitamin D’s influence extends to other areas of health. For example, in the context of stem cell transplantation, vitamin D’s immunomodulatory properties are being investigated for their potential impact on transplant outcomes. Deficiency in vitamin D has been linked to complications such as graft-versus-host disease, indicating its importance in post-transplant care. Furthermore, vitamin D levels have been associated with the severity of diabetic retinopathy, suggesting its role in ocular health. These diverse associations underscore the broad relevance of vitamin D as a biomarker in both clinical and research settings.

This product is manufactured in USA by Eagle Biosciences.