Hemopexin is a plasma glycoprotein primarily synthesized by the liver that binds free heme with high affinity, protecting tissues from heme-mediated oxidative damage. In mice, as in humans, hemopexin plays a crucial role in heme scavenging, antioxidant defense, and regulation of iron homeostasis. Because free heme can be highly cytotoxic and pro-inflammatory, hemopexin serves as an important biomarker of hemolysis, oxidative stress, and inflammatory states.
In research settings, mouse hemopexin is used to study hemolytic disorders, oxidative stress, liver function, and inflammatory diseases. It helps researchers monitor systemic responses to hemolysis or tissue injury, evaluate the protective effects of therapeutic interventions, and investigate mechanisms of heme detoxification and iron metabolism. Hemopexin levels are often assessed alongside other acute-phase proteins to understand the broader context of immune and metabolic responses in experimental models.
In clinical and translational contexts, measuring hemopexin in mouse models can simulate human conditions such as hemolytic anemia, sepsis, malaria, or transfusion-related injuries, where free heme is elevated. Quantifying hemopexin provides insights into disease severity, tissue damage, and the efficacy of heme-scavenging therapies. These studies are critical for developing interventions aimed at mitigating oxidative damage and inflammation associated with excessive free heme, bridging preclinical findings to potential clinical applications.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 4.268 ng/mL |
| Dynamic Range | 12.5 ng/mL – 400 ng/mL |
| Incubation Time | 1 hour 30 minutes |
| Sample Type | Serum, plasma |
| Storage | 2-8°C |
| Alternative Names | Hpx, Heme-binding plasma protein, Plasma heme scavenger |