Fibrinogen is a 340-kDa glycoprotein produced by the liver and plays a critical role in hemostasis by acting as a precursor to fibrin, the structural component of blood clots. In mice, as in humans, fibrinogen is composed of three pairs of polypeptide chains (Aα, Bβ, and γ), and its levels are tightly regulated in the plasma. It is an acute-phase reactant, meaning its concentration rises significantly in response to systemic inflammation, tissue injury, infection, or other immune challenges. Mouse fibrinogen is structurally and functionally similar to human fibrinogen, making it a valuable model protein for studying coagulation and inflammation in preclinical research.
In a research setting, mouse fibrinogen is frequently used as a biomarker for systemic inflammation, particularly in studies investigating sepsis, cardiovascular disease, wound healing, and autoimmune disorders. Its role in clot formation also makes it a critical component in thrombosis models and studies of hemostatic disorders. Additionally, transgenic or fibrinogen-deficient mouse models allow researchers to dissect the specific roles of fibrinogen in disease pathogenesis and immune responses. Clinically, insights gained from mouse fibrinogen studies contribute to the development of anticoagulant therapies, inflammation-modulating treatments, and diagnostics for clotting abnormalities. Its utility as both a functional molecule and biomarker makes it indispensable in translational research bridging animal models and human disease.
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