MASP-2, a mannan-binding lectin (MBL) associated serine protease, plays a pivotal role in the activation of the complement system. It binds to and activates upon the oligomerization of MBL or L-Ficolin. Crucial in cleavind C4 and C2, MASP-2 is integral for triggering downstream complement proteins. Deficiencies in MASP-2 significantly heighten susceptibility to infections, particularly in vulnerable groups like leukemia patients undergoing chemotherapy. This heightened risk is even more pronounced than in MBL deficiency, given MASP-2’s role in complement activation via H- and L-ficolin.
This product is manufactured in Netherlands by Hycult Biotech.