Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) is the primary binding protein for insulin-like growth factors (IGF-1 and IGF-2) in circulation, regulating their bioavailability and activity. In mice and rats, IGFBP-3 plays a crucial role in growth, development, and metabolism by modulating IGF signaling, which influences cell proliferation, differentiation, and survival. Alterations in IGFBP-3 levels are associated with various physiological and pathological conditions, including growth disorders, metabolic dysfunction, cancer, and age-related diseases, making it a valuable biomarker for studying IGF-related pathways.
The Mouse/Rat IGFBP-3 ELISA (enzyme-linked immunosorbent assay) is designed to quantitatively measure IGFBP-3 levels in serum, plasma, or tissue samples from rodents. In research settings, this assay is widely used to investigate growth regulation, endocrine function, and metabolic pathways. It is particularly useful in studies examining the effects of genetic modifications, nutritional interventions, or drug treatments on IGF signaling and IGFBP-3 expression.
In preclinical and translational research, the Mouse/Rat IGFBP-3 ELISA provides important information on disease models, including cancer, diabetes, and obesity. By monitoring IGFBP-3 levels, researchers can assess the impact of therapeutic strategies on IGF-mediated pathways, helping to elucidate mechanisms of disease progression and treatment response. Although primarily used in research, these findings can inform clinical studies and guide the development of IGF-targeted therapies.
This product is manufactured in by Mediagnost.
| Size | 1 x 96 Well |
| Sensitivity | 0.018 ng/mL |
| Dynamic Range | 0.78 – 5 ng/mL |
| Incubation Time | 2 hours 30 minutes |
| Sample Type | Serum, Plasma |
| Alternative Names | Insulin-like growth factor-binding protein 3, IGFBP3, and Acid-labile subunit-binding protein 3. |
