Kidney Injury Molecule-1 (KIM-1) is a type I transmembrane glycoprotein expressed at low levels in healthy kidneys but strongly upregulated in proximal tubular epithelial cells following kidney injury. It plays a role in the repair process by mediating phagocytosis of apoptotic cells and debris, as well as modulating inflammation and tissue remodeling. Because KIM-1 expression is highly specific to injured renal tissue, it has emerged as a sensitive and early biomarker for acute kidney injury (AKI) and other renal pathologies, allowing detection before traditional markers like serum creatinine show changes.
The KIM-1 ELISA enables quantitative measurement of KIM-1 levels in urine or serum, providing a non-invasive method to assess renal injury. In research, KIM-1 ELISAs are widely used to study mechanisms of nephrotoxicity, evaluate drug-induced kidney injury, and investigate the molecular pathways involved in kidney repair and fibrosis. It also serves as a tool for preclinical and translational studies in models of acute or chronic kidney disease.
Clinically, KIM-1 measurement can help detect early-stage kidney injury in hospitalized patients, those undergoing nephrotoxic treatments, or individuals at high risk of AKI, such as post-surgical or critical care patients. It may also be useful in monitoring disease progression in chronic kidney disease and assessing the efficacy of therapeutic interventions aimed at protecting or restoring renal function. By providing an early and specific indicator of tubular damage, KIM-1 ELISA supports timely clinical decision-making and improved patient outcomes.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 0.054 ng/mL |
| Dynamic Range | 0.125 ng/mL – 4 ng/mL |
| Incubation Time | 1 hour 50 minutes |
| Sample Type | Serum, plasma, urine |
| Storage | 2-8°C |
| Alternative Names | Kidney Injury Molecule-1, HAVCR1, and TIM-1. |