Humanized Anti-Her2/neu (Herceptin/Trastuzumab) ELISA Kit

$980.00

The Eagle Biosciences Humanized Anti-HER-2 (Herceptin/Trastuzumab) ELISA Assay kit is intended for use in the quantitative determination of Herceptin levels in human serum and EDTA plasma. The Eagle Biosciences Humanized Anti-HER-2 (Herceptin/Trastuzumab) ELISA Assay kit is intended for research use only.

SKU: AHR31-K01 Category: Tags: , ,

Trastuzumab (Herceptin) is a humanized monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2), a transmembrane tyrosine kinase receptor involved in cell proliferation and survival. HER2 is overexpressed in approximately 15–20% of breast cancers and in a subset of gastric and gastroesophageal cancers, often correlating with aggressive disease and poor prognosis. Trastuzumab binds to the extracellular domain of the HER2 receptor, inhibiting its signaling, promoting antibody-dependent cellular cytotoxicity (ADCC), and preventing receptor dimerization. This mechanism effectively halts tumor growth and facilitates immune-mediated destruction of cancer cells.

In clinical settings, Trastuzumab is used primarily in the treatment of HER2-positive breast cancer, both in early-stage and metastatic disease. It is often combined with chemotherapy agents such as paclitaxel or docetaxel, and its use has significantly improved survival outcomes for patients with HER2-positive tumors. Beyond breast cancer, Trastuzumab is approved for HER2-positive metastatic gastric and gastroesophageal junction cancers. In research, it serves as a model therapeutic for studying monoclonal antibody mechanisms, resistance pathways (e.g., HER2 mutations or compensatory signaling), and the development of biosimilars. It is also a key component in evaluating novel HER2-targeted therapies, including antibody-drug conjugates and bispecific antibodies.

This product is manufactured in USA by Eagle Biosciences.

Size 1 x 96 Well
Sensitivity 0.0077 µg/mL
Dynamic Range 0.245 – 500 ng/mL
Incubation Time 2 hours
Sample Type Serum, EDTA plasma
Immunogen
Source Species
Specificity
Expression System
Clone
Group
Alpha Chain
Beta Chain
Peptide
Peptide Source
Format
Buffer
Concentration
Storage 2-8°C
Alternative Names Trastuzumab, Trazimera, Anti-HER2 antibody
Instructions For Use https://eaglebio.com/wp-content/uploads/products/Eagle-Box-color-gastro-2.png, https://eaglebio.com/wp-content/uploads/products/Eagle-Box-plain.png
MSDS https://eaglebio.com/wp-content/uploads/2017/10/AHR31-K01-Humanized-Anti-HER-2-ELISA-Kit-MSDS.pdf

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