Human Anti-Mouse Antibody (HAMA) ELISA Kit

Human Anti-Mouse Antibody (HAMA) refers to human antibodies that specifically recognize and bind to mouse immunoglobulins. These antibodies commonly arise in individuals exposed to murine-derived monoclonal antibodies or diagnostic reagents. Because many early therapeutic and diagnostic monoclonal antibodies were produced in mice, repeated exposure could stimulate the human immune system to form anti-mouse responses. HAMA belongs to the broader category of human anti-animal antibodies (HAAA) and can include IgG, IgM, or IgE isotypes, depending on the nature of the immune response.

In research settings, HAMA is used as a biomarker of immunogenicity, helping investigators evaluate human immune responses to mouse-derived therapeutics or hybridoma-based reagents. Detecting HAMA can help assess the potential for assay interference in immunoassays that use murine antibodies, as HAMA may bridge assay antibodies and cause false-positive or false-negative results. Consequently, HAMA detection and mitigation strategies are critical in assay validation and quality control for reliable biomarker quantification.

In clinical settings, monitoring HAMA is important for patients undergoing treatment with murine or chimeric monoclonal antibodies, such as early cancer immunotherapies or diagnostic imaging agents. The presence of HAMA can alter the pharmacokinetics, efficacy, and safety of these therapies by accelerating clearance or inducing hypersensitivity reactions. Therefore, identifying HAMA serves both as a diagnostic biomarker of immune reactivity and as a predictive biomarker for treatment response and adverse effects, guiding clinicians in therapeutic decision-making and patient management.

This product is manufactured in USA by Eagle Biosciences.