High Sensitive Anti-Tg IgG is an autoantibody directed against thyroglobulin (Tg), a key precursor protein involved in the synthesis of thyroid hormones. The presence of anti-Tg autoantibodies in serum is commonly associated with autoimmune thyroid diseases, including Hashimoto’s thyroiditis and Graves’ disease. Detecting these autoantibodies is a routine clinical practice to aid in the diagnosis and monitoring of thyroid dysfunction. Anti-Tg antibodies are particularly valuable in assessing the autoimmune activity within the thyroid gland, where they correlate with underlying histological changes.
In the clinical setting, the detection of high sensitive anti-Tg IgG serves as a biomarker for patients presenting with thyroid disorders such as chronic thyroiditis, hypothyroidism, and thyrotoxicosis. Although anti-Tg antibodies are less frequently observed in thyroid tumors, their presence still contributes to the overall assessment of thyroid autoimmunity. The improved ELISA-based assays with enhanced sensitivity and reduced background reactivity in healthy populations—such as the EDI™ high sensitivity anti-Tg IgG test—offer a more reliable tool for identifying autoimmune thyroid conditions with greater specificity and diagnostic accuracy.
In research, high sensitive anti-Tg IgG is used to explore the pathogenesis of autoimmune thyroiditis and to monitor the effectiveness of treatment strategies aimed at modulating autoimmune responses. Its inclusion in diagnostic panels alongside anti-TPO antibodies helps provide a comprehensive view of thyroid autoimmunity, contributing to early detection, disease stratification, and management planning in both clinical trials and routine endocrinology practice.
This product is manufactured in USA by Eagle Biosciences.