Guinea Pig C3 ELISA Kit

Complement component 3 (C3) is a central protein in the complement system, a key part of the innate immune response responsible for opsonization, inflammation, and pathogen lysis. In guinea pigs (Cavia porcellus), C3 shares significant structural and functional homology with human and other mammalian C3 proteins, making it a valuable model for immunological studies. Guinea pig C3 consists of multiple subunits formed by proteolytic cleavage of a precursor molecule and functions by binding to pathogens or immune complexes, facilitating phagocytosis and activation of downstream complement pathways.

Research Applications:
Guinea pig C3 is extensively used in immunological research due to the guinea pig’s robust complement activity and similarity to human immune responses. It serves as a biomarker for assessing complement activation, immune complex formation, and inflammatory responses in experimental models of infection, autoimmunity, and hypersensitivity. Studies involving guinea pig C3 have contributed to the understanding of complement-mediated hemolysis, antibody-dependent cytotoxicity, and vaccine efficacy. The guinea pig complement system is particularly favored in classical complement assays, such as hemolytic activity tests, due to its high sensitivity and reproducibility.

Clinical and Translational Relevance:
Although guinea pig C3 itself is not directly applied in clinical diagnostics, insights gained from its study support translational research into human complement-related diseases. Experimental models using guinea pig C3 help elucidate mechanisms underlying disorders like lupus, rheumatoid arthritis, and complement deficiencies. Moreover, guinea pig-derived C3 reagents are sometimes used to evaluate the efficacy of complement inhibitors and immunotherapeutic agents, bridging preclinical and clinical research by providing a physiologically relevant model for human immune system behavior.

This product is manufactured in USA by Eagle Biosciences.