GABA ELISA Kit

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, playing a crucial role in regulating neuronal excitability, maintaining the balance between excitation and inhibition, and modulating anxiety, sleep, and motor control. GABA is synthesized from glutamate by the enzyme glutamic acid decarboxylase (GAD) and acts by binding to GABA receptors (GABA_A and GABA_B), which mediate fast and slow inhibitory signaling, respectively. As a biomarker, GABA reflects inhibitory neurotransmission and overall neural network activity, making it important in both neuroscience research and clinical studies.

In research, GABA is measured to investigate neural circuitry, synaptic function, and the pathophysiology of neurological and psychiatric disorders. Alterations in GABA levels or signaling are studied in models of epilepsy, anxiety, depression, schizophrenia, and neurodegenerative diseases. Techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, or magnetic resonance spectroscopy (MRS) are used to quantify GABA in brain tissue, cerebrospinal fluid, or plasma, providing insights into inhibitory neurotransmission and the effects of pharmacological interventions.

Clinically, GABA serves as a biomarker for disorders involving dysregulated inhibitory signaling. Reduced GABA activity is associated with epilepsy, anxiety disorders, and certain forms of cognitive dysfunction, while modulation of GABA receptors is a target for anxiolytic, sedative, and anticonvulsant therapies. Measuring GABA levels can help monitor disease progression, therapeutic response, and the effects of drugs that target GABAergic pathways, bridging basic neuroscience research with clinical applications in neurology and psychiatry.

This product is manufactured in Germany by LDN.