Feline Immunoglobulin G (IgG) is the most abundant antibody isotype in the serum of cats and plays a central role in adaptive immunity. Structurally, feline IgG is a Y-shaped glycoprotein composed of two heavy and two light chains, functioning to recognize and neutralize pathogens such as bacteria, viruses, and toxins. It is produced by plasma cells in response to antigen exposure and contributes to long-term immune memory. The detection and quantification of feline IgG serve as important indicators of immune status, either reflecting prior exposure to infectious agents or evaluating the effectiveness of vaccination responses in cats.
In research settings, feline IgG is widely used as a biomarker to assess humoral immune responses in studies of infectious diseases (e.g., feline immunodeficiency virus, feline leukemia virus, and coronaviruses) and vaccine efficacy. Quantitative assays such as enzyme-linked immunosorbent assays (ELISA) and immunoblotting are commonly employed to measure IgG levels, providing valuable data on antigen-specific immunity and immune modulation. Furthermore, purified feline IgG is often used as a control or standard in immunodiagnostic assay development and comparative immunology studies to better understand species-specific immune mechanisms.
Clinically, the measurement of feline IgG is useful in diagnosing immunodeficiencies, evaluating passive immunity transfer in kittens, and monitoring immune responses post-vaccination or infection. For instance, low IgG levels in neonatal kittens can indicate failure of passive transfer from maternal colostrum, while elevated or antigen-specific IgG titers may confirm recent or ongoing immune activation. Thus, feline IgG serves as a critical biomarker for both fundamental research and applied veterinary diagnostics, contributing to improved understanding and management of feline health and disease.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 4.095 ng/mL |
| Dynamic Range | 12.5 ng/mL – 800 ng/mL |
| Incubation Time | 1 hour 20 minutes |
| Sample Type | Plasma, Serum |
| Storage | 2-8°C |
| Alternative Names | Cat immunoglobulin G, feline gamma globulin, cat IgG antibody, and feline immunoglobulin gamma. |