Estradiol (E2) is a primary estrogen steroid hormone and a critical biomarker in both clinical and research settings. Synthesized mainly in the ovaries, estradiol plays a central role in the regulation of the menstrual cycle and reproductive system. It also has important effects on bone density, cardiovascular health, and the central nervous system. In the context of biomarkers, estradiol is often measured to assess ovarian function, monitor hormone replacement therapy, and evaluate endocrine disorders. In women, serum estradiol levels vary throughout the menstrual cycle, making it useful in fertility assessments and in monitoring ovulation induction during assisted reproductive technologies.
In research, estradiol serves as a key indicator in studies exploring hormonal regulation, endocrine-disrupting chemicals, and sex-based differences in disease mechanisms. Clinically, estradiol measurements are used in diagnosing and managing conditions such as amenorrhea, polycystic ovary syndrome (PCOS), and estrogen-secreting tumors. It is also monitored in transgender hormone therapy, menopausal hormone replacement, and in the evaluation of bone health. Accurate assessment typically requires highly sensitive assays like liquid chromatography–mass spectrometry (LC-MS) or immunoassays. Given its dynamic physiological role and diagnostic value, estradiol remains a pivotal biomarker in both endocrine research and patient care.
This product is manufactured in USA by Eagle Biosciences.