Creatinine is a waste product generated from the normal metabolism of creatine, primarily in muscle tissue. It is produced at a relatively constant rate and is excreted by the kidneys, making it a widely used biomarker for kidney function. Because creatinine clearance reflects glomerular filtration rate (GFR), its concentration in blood (serum or plasma) and urine is commonly measured to assess renal function and detect early signs of kidney impairment.
In research, creatinine is used to study renal physiology, kidney disease models, and the effects of drugs or toxins on renal function. It provides a standard reference for normalizing other urinary biomarkers, enabling accurate comparison of metabolite excretion across samples. Animal studies often measure creatinine to evaluate nephrotoxicity, renal clearance, and the progression of kidney-related disorders in experimental models.
Clinically, creatinine is routinely measured to diagnose and monitor kidney disease, guide dosing of renally excreted medications, and assess overall renal health. It is also used in combination with formulas such as the estimated glomerular filtration rate (eGFR) to provide a more precise evaluation of kidney function. Elevated creatinine levels can indicate impaired renal filtration, dehydration, or muscle breakdown, whereas unusually low levels may reflect reduced muscle mass or certain medical conditions. Overall, creatinine is an essential biomarker linking basic research with clinical assessment of renal function and systemic health.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 1.0 mg/dL |
| Dynamic Range | 1.0 – 10 mg/dL |
| Incubation Time | 15 minutes |
| Sample Type | Urine |
| Storage | 2-8°C |
| Alternative Names | methylguanidine-acetic acid, 2-amino-1-methyl-5H-imidazol-4-one, or creatinine nitrogen compound. |
