Osteopontin (OPN), also known as secreted phosphoprotein 1 (SPP1), is a multifunctional glycoprotein involved in bone remodeling, inflammation, and immune regulation. In dogs, as in other species, osteopontin is expressed in various tissues including bone, kidney, and immune cells, and is secreted in response to injury or inflammatory stimuli. It binds to integrins and CD44 receptors, mediating cell adhesion, migration, and signaling pathways associated with tissue repair and immune modulation. Because of its pleiotropic roles, canine osteopontin has gained attention as a potential biomarker for several pathological conditions.
In research settings, canine OPN is studied as a biomarker of inflammation, fibrosis, and cancer progression. Elevated OPN levels have been associated with diseases such as canine osteosarcoma, renal disease, and cardiovascular disorders. For example, increased OPN expression in osteosarcoma tissues correlates with tumor aggressiveness and metastatic potential, making it a useful molecular target for understanding tumor biology and developing diagnostic or prognostic tools. Similarly, in kidney disease, urinary and serum OPN levels may reflect tubular injury and inflammatory responses, providing insight into disease mechanisms and progression.
Clinically, osteopontin has potential applications as a diagnostic and prognostic biomarker in veterinary medicine. Measuring circulating or tissue OPN levels could aid in early detection, monitoring of disease activity, and evaluation of treatment response in dogs with cancer, inflammatory, or renal disorders. Furthermore, given its conserved structure and functions across species, canine OPN serves as a valuable translational model for studying human diseases involving inflammation and metastasis. Continued research into the regulation and clinical significance of OPN in dogs may enhance its use as both a biomarker and a therapeutic target in veterinary and comparative medicine.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 0.07 ng/mL |
| Dynamic Range | 10 ng/mL-0.3125 ng/mL |
| Incubation Time | 2 hours 50 minutes |
| Sample Type | Plasma, urine |
| Storage | 2-8°C |
| Alternative Names | Secreted phosphoprotein 1 (SPP1), bone sialoprotein I, early T-lymphocyte activation 1 (ETA-1), urinary stone protein, and nephropontin. |