Human ultra sensitive C-peptide is a refined biomarker used to detect extremely low levels of C-peptide in the bloodstream, enabling more precise assessment of endogenous insulin production. C-peptide, a 31-amino acid peptide, is cleaved from proinsulin during the formation of insulin in the pancreatic beta cells and circulates in equimolar amounts with insulin. Due to its longer half-life—approximately three to four times that of insulin—C-peptide serves as a more stable and reliable marker of beta-cell function.
In clinical practice, ultra sensitive C-peptide assays are especially valuable for evaluating residual beta-cell activity in patients with long-standing diabetes, particularly type 1 diabetes where C-peptide levels may be extremely low. These measurements aid in distinguishing between type 1 and type 2 diabetes, investigating causes of hypoglycemia, and monitoring disease progression or therapeutic interventions. In individuals with insulin resistance (type 2 diabetes), preserved or elevated C-peptide levels indicate adequate insulin production with poor cellular response.
Research suggests that beyond glucose metabolism, C-peptide may exert biological effects such as influencing inflammatory pathways. Studies have implicated C-peptide in the chemotaxis of immune cells and a potential role in promoting atherosclerotic changes, especially in individuals with type 2 diabetes. Ultra sensitive assays thus offer a powerful tool for both clinical diagnostics and metabolic or cardiovascular research.
This product is manufactured in USA by Eagle Biosciences.
Size | 1 x 96 Well |
Sensitivity | 0.57 pg/mL |
Dynamic Range | 8.6 pg/ml- 700 pg/ml |
Incubation Time | 2 hours 20 minutes |
Sample Type | Serum, EDTA-Plasma |
Immunogen | |
Source Species | |
Specificity | |
Expression System | |
Clone | |
Group | |
Alpha Chain | |
Beta Chain | |
Peptide | |
Peptide Source | |
Format | |
Buffer | |
Concentration | |
Storage | 2-8°C |
Alternative Names | Connecting peptide, Proinsulin C-peptide, Insulin C-peptide, C-peptide of insulin, C-terminal peptide of proinsulin, Beta-cell peptide, Human pancreatic C-peptide, Insulin precursor peptide, C-insulin peptide, Endogenous insulin marker. |
Instructions For Use | |
MSDS | https://eaglebio.com/wp-content/uploads/2014/08/CPU31-K01-C-Peptide-Ultrasensitive-ELISA-Kit-MSDS.pdf |