Beta-2 microglobulin (β2M) is a low-molecular-weight protein that forms part of the major histocompatibility complex (MHC) class I molecules present on the surface of nearly all nucleated cells. It is continuously shed into the bloodstream and is filtered by the kidneys, making its serum levels a useful indicator of cellular turnover and kidney function. Elevated β2M levels often reflect increased immune activation or cellular destruction, and because it is cleared by the kidneys, levels rise in cases of impaired renal function.
In clinical and research settings, β2M is widely used as a biomarker for monitoring kidney disease progression, especially in conditions like chronic kidney disease and dialysis-related amyloidosis. It also serves as a prognostic marker in hematological malignancies such as multiple myeloma and lymphoma, where high β2M levels often correlate with disease burden and poorer outcomes. Additionally, β2M is used to assess immune system activity in autoimmune diseases and infections, making it a versatile marker for both renal and immune-related conditions.
This product is manufactured in USA by Eagle Biosciences.