Anti-Phosphatidylserine (aPS) antibodies are autoantibodies that target phosphatidylserine, a negatively charged phospholipid normally located on the inner leaflet of the cell membrane. During apoptosis or cell activation, phosphatidylserine translocates to the outer membrane, where it can become immunogenic. The presence of aPS antibodies is associated with autoimmune and thrombotic disorders, as these antibodies can interfere with coagulation pathways and promote inflammation. They are often studied alongside other antiphospholipid antibodies due to their role in antiphospholipid syndrome (APS) and related conditions.
The Anti-Phosphatidylserine ELISA allows for the quantitative detection of these autoantibodies in serum or plasma. In research settings, aPS ELISAs are used to investigate mechanisms of autoimmune disease, particularly how autoantibodies contribute to thrombotic events, pregnancy complications, and vascular inflammation. They also help in the study of immune system dysregulation and the development of novel therapeutics targeting autoantibody-mediated pathways.
Clinically, aPS ELISA is used as part of the diagnostic workup for antiphospholipid syndrome and other autoimmune disorders. Detection of these antibodies can assist in assessing thrombotic risk, guiding anticoagulant therapy, and monitoring disease progression in patients with recurrent miscarriages, deep vein thrombosis, or systemic lupus erythematosus. The assay provides a sensitive and specific method to complement other antiphospholipid antibody tests, supporting both diagnosis and long-term patient management.
This product is manufactured in Germany by Medipan GmbH.
| Size | 1 x 96 Well |
| Sensitivity | 3 U/mL |
| Dynamic Range | 3 -300 U/mL |
| Incubation Time | 2 hours 30 minutes |
| Sample Type | Serum |
| Storage | 2-8°C |
| Alternative Names | Antiphosphatidylserine antibody, anti-PS antibody, aPS antibody, and anti-phosphatidylserine IgG. |
