Anti-IA2 ELISA Kit kit

Anti-IA2 antibodies (IA-2A) are autoantibodies directed against insulinoma-associated protein 2 (IA-2), a tyrosine phosphatase-like protein localized in the secretory granules of pancreatic β-cells. IA-2 is involved in the regulation of insulin secretion and vesicle trafficking within the islets of Langerhans. The presence of anti-IA2 antibodies reflects an autoimmune response targeting pancreatic β-cells, leading to their destruction and the subsequent development of type 1 diabetes mellitus (T1DM). These antibodies typically appear in the preclinical phase of the disease, often alongside other islet autoantibodies such as anti-GAD65, anti-insulin, and anti-ZnT8.

In the clinical setting, anti-IA2 antibody testing is used as a biomarker for autoimmune diabetes, aiding in the diagnosis and classification of T1DM, particularly in distinguishing it from type 2 diabetes or other atypical forms. IA-2A positivity, especially in combination with other islet autoantibodies, strongly predicts progression to overt diabetes in at-risk individuals, such as relatives of patients with T1DM. The presence of multiple islet autoantibodies, including IA-2A, indicates a high likelihood of β-cell autoimmunity and impending clinical onset.

In research, anti-IA2 antibodies serve as crucial tools for studying the immunopathogenesis of T1DM. They are used in longitudinal cohort studies to identify individuals at risk and to track the natural history of autoimmune β-cell destruction. IA-2A measurements are also valuable in clinical trials assessing preventive or immunomodulatory therapies, as changes in antibody titers can reflect immune intervention effects. Thus, IA-2A remains a key biomarker bridging both clinical diagnostics and autoimmune diabetes research.

This product is manufactured in Germany by Medipan GmbH.