Anti-Factor H ELISA Kit (48 Wells)

Anti-Factor H (Anti-FH) antibodies are autoantibodies directed against complement factor H, a key regulator of the alternative complement pathway. Factor H normally inhibits uncontrolled complement activation on host cells, protecting tissues from damage. When autoantibodies target Factor H, this regulation is disrupted, leading to excessive complement activity, endothelial injury, and increased risk of thrombotic microangiopathies. Anti-FH antibodies are most commonly associated with atypical hemolytic uremic syndrome (aHUS), a rare but severe kidney disorder, and can also play a role in other complement-mediated diseases. Their presence serves as an important biomarker for disease pathogenesis and patient stratification.

The Anti-FH ELISA (enzyme-linked immunosorbent assay) provides a sensitive and specific method to detect and quantify these autoantibodies in serum or plasma. In research settings, this assay is used to study the mechanisms of complement dysregulation, investigate the role of autoantibodies in disease progression, and evaluate potential therapeutic interventions targeting complement pathways. It also helps in characterizing patient subgroups for precision medicine studies focused on complement-mediated disorders.

Clinically, Anti-FH ELISA is primarily used to aid in the diagnosis and prognosis of aHUS and other complement-driven conditions. Detecting these antibodies can help distinguish antibody-mediated aHUS from genetic forms, guiding treatment decisions such as the use of complement inhibitors or immunosuppressive therapy. Monitoring Anti-FH antibody levels over time can also provide insight into disease activity, risk of relapse, and treatment response, making it a valuable tool in patient management and clinical decision-making.

This product is manufactured in Germany by Medipan GmbH.