Anti-beta1 adrenergic recptor antibodies (IgG) ELISA Kit

The Anti-beta1 Adrenergic Receptor Antibodies (IgG) ELISA Kit is used to measure IgG-class autoantibodies directed against the beta1 adrenergic receptor (beta1 -AR), a G-protein–coupled receptor that regulates cardiac rhythm, contractility, and sympathetic nervous system signaling. Autoantibodies targeting beta1 -AR have been implicated in various cardiovascular conditions, particularly certain forms of autoimmune-mediated cardiomyopathy and arrhythmias. Because these antibodies can functionally modulate receptor activity, their detection is valuable for understanding disease mechanisms and evaluating potential biomarkers in cardiac research.

In this ELISA format, purified beta1-AR antigens—often derived from synthetic peptides corresponding to extracellular receptor domains—are immobilized on a microplate to capture beta1 -AR-specific IgG antibodies from serum samples. After binding, enzyme-labeled secondary antibodies enable colorimetric detection, with signal intensity reflecting the concentration of anti-beta1-AR IgG. The assay provides a sensitive, reproducible method for quantifying these functionally relevant autoantibodies.

Research applications of the Anti-beta1 Adrenergic Receptor Antibodies (IgG) ELISA Kit include studying autoimmune contributions to dilated cardiomyopathy, chronic heart failure, and arrhythmic disorders; monitoring antibody levels in experimental therapeutic interventions; and evaluating their potential as diagnostic or prognostic biomarkers. Because beta1-AR plays a central role in cardiac physiology, understanding the presence and activity of these autoantibodies can offer important insights into disease progression and targeted treatment strategies.

This product is manufactured in Germany by CellTrend GmbH.