We have been very busy these past few months gathering a bunch of new products to offer our great and loyal customers! Some of these new products have been added to our ever-growing Bone Metabolism Assays.
Research on the effects of various cancers and abnormalities in the skeletal system are on the rise and we are excited to start offering more tests!
Soluble Semaphorin 4D ELISA:
For the direct determination of soluble Semaphorin 4D in human plasma samples.
Semaphorin 4D (SEMA4D or CD100) is a member of a family of trans membranes and secreted proteins that regulates key cellular functions and is involved in cell-cell communication. SEMA4D participates in numerous physiological processes such as axon guidance, immune regulation, angiogenesis, tumor progression, and bone metabolism. SEMA4D has emerged to a novel therapeutic target in cancer and in bone diseases.
Bioactive Sclerostin ELISA:
For the quantitative determination of bioactive sclerostin in human serum, EDTA plasma, and citrate plasma.
Sclerostin is nearly exclusively produced in osteocytes. Mutations in the Sclerostin (SOST) gene can cause sclerosteosis and van Buchem disease which are bone dysplasia disorders characterized by progressive skeletal overgrowth. Sclerostin levels are altered in response to hormonal stimuli or due to pathophysiological conditions. Sclerostin concentrations are increased in disorders such as hypoparathyroidism, Paget’s disease, multiple myeloma and in cancer induced bone diseases.
OsteomiR (Coming Soon!)
For the quantification of selected microRNA biomarker candidates for fracture-risk in postmenopausal and diabetic osteoporosis in human serum samples.
MicroRNAs are small non-coding RNAs that regulate gene expression through RNA interference and therefore contribute to the regulation of correct cell and tissue function. MicroRNA secretion (contained in exosomes or microvesicles) has been observed in many different cell types, and is believed to serve as an endocrine pathway for cell-to-cell communication. Therefore, the analysis of circulating microRNAs in serum, urine or saliva can be used to obtain valuable information about tissue physiology and pathophysiology. Circulating microRNAs are a novel class of relevant serum biomarkers.
Keep an eye out for all the other great new products we are releasing in the next few months!
Looking for a specific ELISA? Email us what you’re looking for and we can try to make it happen!