Intact FGF-21 ELISA Kit
Fibroblast Growth Factor 21 (FGF-21) is a liver-derived metabolic hormone involved in regulating glucose and lipid metabolism, energy expenditure, and insulin sensitivity. It is part of the endocrine FGF subfamily and requires β-Klotho as a co-receptor for signaling. Among its various forms, intact FGF-21 refers to the full-length, biologically active protein capable of engaging FGF receptors and eliciting physiological effects. This intact form is distinct from degraded or fragmented variants, which may circulate in the bloodstream but lack functional activity. As a biomarker, intact FGF-21 is typically measured in serum or plasma using highly specific immunoassays, which differentiate it from inactive fragments, allowing more accurate assessment of its metabolic roles.
In research and clinical settings, intact FGF-21 is increasingly studied for its diagnostic and prognostic utility in metabolic disorders. Elevated levels have been observed in individuals with obesity, type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and mitochondrial disorders, reflecting compensatory upregulation in response to metabolic stress. Unlike total FGF-21, which includes inactive fragments, intact FGF-21 more accurately correlates with disease severity and therapeutic response. Clinically, it is being investigated as a biomarker for early detection of mitochondrial dysfunction, as well as a predictor of cardiovascular and renal complications in metabolic syndromes. Moreover, ongoing trials are exploring FGF-21 analogs as therapeutic agents, making the measurement of intact FGF-21 vital for monitoring drug efficacy and guiding personalized treatment strategies. Its dynamic regulation and tissue specificity position intact FGF-21 as a promising biomarker bridging metabolic health and precision medicine.
This Intact FGF-21 ELISA Kit is manufactured in USA by Eagle Biosciences.
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