Corticosterone EIA Kit

Corticosterone is a glucocorticoid hormone produced primarily by the adrenal cortex and plays a central role in regulating energy balance, stress responses, and immune modulation. While cortisol is the dominant glucocorticoid in humans, corticosterone is the primary glucocorticoid in rodents, birds, and some other species, making it especially important for comparative endocrinology and translational research. Its synthesis and release are controlled by the hypothalamic–pituitary–adrenal (HPA) axis, where corticosterone acts as a key downstream effector that helps maintain homeostasis during physiological and psychological stress.
In research settings, corticosterone is widely measured as a biomarker of stress, metabolic status, circadian rhythms, and behavioral responses, particularly in rodent models. It is essential for studies investigating neuroendocrine signaling, immune suppression, anxiety- and depression-related behaviors, and drug or environmental stressor effects. Because corticosterone varies with time of day, environmental conditions, and handling stress, it is often used to monitor the integrity of experimental models or to validate interventions targeting the HPA axis.
Clinically, corticosterone has limited direct diagnostic use in humans compared to cortisol, but it may serve as a secondary biomarker when evaluating adrenal disorders, congenital adrenal hyperplasia variants, or enzymatic deficiencies that alter steroid biosynthesis (e.g., 11β-hydroxylase deficiency). In veterinary and wildlife medicine, corticosterone measurement is more routinely applied for assessing stress, welfare, and physiological status across species where it is the dominant glucocorticoid. Its measurement in blood, saliva, hair, or feces provides valuable insight into acute and chronic stress exposure.

This product is manufactured in Canada by StressMarq.