The Anti-FGFR-3 Autoantibodies ELISA Kit is designed to detect autoantibodies directed against fibroblast growth factor receptor 3 (FGFR-3), a transmembrane tyrosine-kinase receptor involved in cell growth, differentiation, and tissue maintenance. FGFR-3 plays an important role in skeletal development and is expressed in various tissues, including cartilage, skin, and the nervous system. Autoantibodies targeting FGFR-3 have been associated with certain neuropathies and autoimmune conditions, making their detection useful for both clinical research and mechanistic studies.
In a typical ELISA format, recombinant FGFR-3 or its relevant antigenic domain is coated onto a microplate to capture FGFR-3–specific autoantibodies from serum or plasma samples. Bound autoantibodies are then detected with enzyme-linked secondary antibodies that produce a colorimetric signal proportional to their concentration. This standardized setup allows researchers to quantify autoantibody levels with high sensitivity and reproducibility.
Applications of the Anti-FGFR-3 Autoantibodies ELISA Kit include investigating autoimmune mechanisms in sensory or motor neuropathies, evaluating biomarkers for disease diagnosis or progression, and exploring the role of FGFR-3–directed immune responses in broader inflammatory or degenerative conditions. Because FGFR-3 signaling influences neural and musculoskeletal physiology, the presence of these autoantibodies can provide valuable insights into disease pathways and potential therapeutic targets.
This product is manufactured in Germany by CellTrend GmbH.
| Size | 1 x 96 Well |
| Sensitivity | 0.8 U/ml |
| Dynamic Range | 1.25 U/mL – 40 U/mL |
| Incubation Time | 3 hours 20 minutes |
| Sample Type | Serum, Plasma |
| Storage | 2-8°C |
| Alternative Names | FGFR3-reactive autoantibodies, FGFR3-targeting autoantibodies, anti–fibroblast growth factor receptor 3 autoantibodies, FGFR3-specific autoantibodies, or FGFR3-directed autoantibodies |
