Mouse KIM-1 ELISA Kit

The Mouse KIM-1 ELISA Kit is designed to quantitatively measure Kidney Injury Molecule-1 (KIM-1) in mouse serum, plasma, urine, or tissue extracts. KIM-1 is a type I transmembrane glycoprotein that is minimally expressed in healthy kidneys but is rapidly and dramatically upregulated in proximal tubular epithelial cells following injury. Because KIM-1 is shed into bodily fluids during renal damage, it serves as a highly sensitive and early biomarker of acute kidney injury (AKI). Compared with traditional markers like blood urea nitrogen (BUN) or creatinine, KIM-1 can detect tubular injury earlier and with greater specificity.

In research settings, the Mouse KIM-1 ELISA Kit is widely used in studies focused on nephrotoxicity, ischemia-reperfusion injury, sepsis-induced kidney damage, diabetic nephropathy, and other renal pathologies. It is particularly valuable in preclinical toxicology, where KIM-1 levels provide an early indicator of kidney damage caused by investigational drugs, contrast agents, or environmental toxins. The kit’s sensitivity and reproducibility make it well suited for longitudinal monitoring, mechanistic studies, and therapeutic evaluations aimed at preventing or reducing renal injury.

Although this specific assay is not used in clinical diagnostics, mouse KIM-1 data play a critical translational role. KIM-1 is an FDA-qualified biomarker for kidney injury in preclinical drug development, meaning results from mouse studies support decisions on drug safety, dosing, and progression to clinical trials. Insights gained from these models help refine kidney injury detection strategies and guide the development of human diagnostic tools and renal-protective therapies. Thus, the Mouse KIM-1 ELISA Kit is an essential tool linking basic renal research to safety assessment and future clinical applications.

This product is manufactured in USA by Eagle Biosciences.