tPA total ELISA Kit

Human tissue-type plasminogen activator (tPA) is a serine protease that plays a central role in the fibrinolytic system by converting plasminogen into plasmin, which in turn degrades fibrin clots. tPA is primarily produced by endothelial cells and is critical for maintaining vascular patency and regulating blood clot formation. Beyond its hemostatic function, tPA is also involved in processes such as tissue remodeling, wound healing, and neuronal plasticity. Dysregulation of tPA levels has been associated with thrombotic disorders, cardiovascular disease, and certain neurological conditions, making it an important biomarker for both physiological and pathological states.

The tPA Total Antigen ELISA (enzyme-linked immunosorbent assay) allows for the quantitative measurement of total tPA antigen in plasma, serum, or other biological fluids. In research settings, this assay is widely used to investigate the dynamics of the fibrinolytic system, study the effects of drugs on tPA expression or activity, and explore its role in cardiovascular, inflammatory, and neurodegenerative diseases. By measuring total tPA levels, researchers can better understand the balance between coagulation and fibrinolysis under various physiological and experimental conditions.

In clinical applications, tPA Total Antigen ELISA is used to assess patients’ fibrinolytic capacity and identify abnormalities in clot dissolution that may contribute to thrombotic or hemorrhagic disorders. It can aid in the diagnosis and monitoring of conditions such as myocardial infarction, stroke, deep vein thrombosis, and other cardiovascular diseases. Additionally, measuring tPA levels can help evaluate the effectiveness of therapeutic interventions targeting the fibrinolytic pathway, supporting personalized treatment strategies and risk assessment in patients with vascular or hemostatic disorders.

This product is manufactured in by Eagle Biosciences.