Rat tPA total ELISA Kit

Rat Tissue-type Plasminogen Activator (tPA) is a serine protease that plays a central role in the fibrinolytic system by converting plasminogen into plasmin, which in turn degrades fibrin clots. In rats, tPA is primarily produced by endothelial cells and is involved not only in clot resolution but also in processes such as tissue remodeling, angiogenesis, and neuronal plasticity. Measuring total tPA antigen reflects both active and inactive forms of the protein, providing insight into overall tPA expression and regulation under physiological and pathological conditions.

The Rat tPA Total Antigen ELISA allows for precise quantification of tPA levels in plasma, serum, or tissue samples. In research settings, this assay is widely used to study fibrinolysis, cardiovascular diseases, stroke models, and tissue injury responses. It also supports investigations into the regulation of tPA expression, its interaction with inhibitors such as PAI-1, and its role in neurobiological processes and experimental therapies.

In clinical and preclinical contexts, measuring tPA antigen levels can help assess the balance of coagulation and fibrinolysis, monitor disease progression, or evaluate the effects of pharmacological interventions targeting the fibrinolytic system. Although primarily used in animal models for translational research, these measurements provide valuable data for understanding the mechanisms of thrombotic disorders, vascular injury, and potential therapeutic strategies before moving into human studies.

This product is manufactured in by Eagle Biosciences.