Tumor necrosis factor-alpha (TNFα) is a key pro-inflammatory cytokine produced by immune cells such as macrophages, monocytes, neutrophils, T-cells, and natural killer cells. It plays a central role in regulating immune responses by driving the acute-phase reaction, promoting apoptosis, influencing cell proliferation and differentiation, and inhibiting tumor growth and viral replication. TNFα acts as an early mediator of inflammation and is rapidly released following stimulation by bacterial components such as lipopolysaccharides.
Dysregulation of TNFα production is associated with a wide range of inflammatory and degenerative diseases, including Crohn’s disease, ulcerative colitis, rheumatoid arthritis, cancer, and Alzheimer’s disease. Elevated TNFα levels reflect heightened immune activation and tissue inflammation, making it a valuable biomarker for assessing disease severity, monitoring treatment response, and studying inflammatory mechanisms in both clinical and research environments.
The TNFα ELISA provides quantitative measurement of TNFα in serum, plasma, stool, and cell culture supernatants. This allows researchers and clinicians to evaluate inflammatory activity, investigate cytokine signaling pathways, and support therapeutic development in conditions characterized by immune dysregulation.
This product is manufactured in USA by Immundiagnostik AG.
