Anti-M2 antibodies are autoantibodies directed against the E2 component of the pyruvate dehydrogenase complex located in the inner mitochondrial membrane. They are a hallmark of primary biliary cholangitis (PBC), an autoimmune liver disease characterized by progressive destruction of intrahepatic bile ducts. The presence of anti-M2 antibodies reflects an autoimmune response targeting mitochondrial antigens, which contributes to cholestasis, inflammation, and eventual fibrosis in affected individuals. Detection of these antibodies provides insight into autoimmune mechanisms and helps distinguish PBC from other liver disorders.
The Anti-M2 ELISA (enzyme-linked immunosorbent assay) is a sensitive and specific method for measuring the concentration of these autoantibodies in serum. In research settings, Anti-M2 ELISAs are used to study the immunopathogenesis of autoimmune liver diseases, explore correlations between antibody levels and disease progression, and evaluate the effects of experimental immunomodulatory therapies. They are also useful for investigating broader autoimmune responses and mitochondrial autoimmunity in experimental models.
In clinical practice, Anti-M2 ELISA is primarily used for the diagnosis and monitoring of PBC. The presence of anti-M2 antibodies, often alongside biochemical liver function tests, helps confirm diagnosis, particularly in patients with asymptomatic or early-stage disease. Serial measurements can provide information on disease activity and response to therapy, and testing for anti-M2 antibodies is also valuable for differentiating PBC from other cholestatic liver diseases, guiding clinicians in prognosis and treatment planning.
This product is manufactured in Germany by Medipan GmbH.
| Size | 1 x 96 Well |
| Sensitivity | 3 U/mL |
| Dynamic Range | 3 -300 U/mL |
| Incubation Time | 2 hours |
| Sample Type | serum, plasma |
| Storage | 2-8°C |
| Alternative Names | AMA-M2, Anti-Mitochondrial M2 Antibody, M2 Antimitochondrial Antibody, and M2-AMA. |
