Complement component 3 (C3) is a central protein in the complement system, a key part of innate immunity. Produced mainly by the liver, C3 plays a critical role in host defense by mediating opsonization of pathogens, promoting inflammation, and facilitating clearance of immune complexes. Upon activation through the classical, lectin, or alternative complement pathways, C3 is cleaved into C3a and C3b, triggering downstream immune responses. Dysregulation of C3 levels is associated with various pathological conditions, including autoimmune diseases, infections, and inflammatory disorders, making it an important biomarker in both basic research and translational studies.
Rat C3 ELISA is an immunoassay designed to quantitatively measure C3 levels in rat serum, plasma, or tissue samples. In research settings, it is widely used to study immune system function, inflammation, and disease models such as autoimmune conditions, sepsis, or organ injury in preclinical studies. The assay allows researchers to monitor changes in C3 expression, assess complement activation, and evaluate the effects of therapeutic interventions targeting the immune system.
While primarily a research tool, C3 measurement can also inform translational studies with potential clinical implications. Altered C3 levels in animal models can provide insights into human disease mechanisms, help identify novel therapeutic targets, and support the preclinical evaluation of drugs affecting the complement pathway. By providing quantitative data on complement activity, Rat C3 ELISA serves as a valuable tool for both understanding immune responses and guiding the development of treatments for complement-related disorders.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 4.326 ng/mL |
| Dynamic Range | 12.5 – 800 ng/mL |
| Incubation Time | 50 minutes |
| Sample Type | Serum, plasma |
| Storage | 2-8°C |
| Alternative Names | Complement C3, Third Component of Complement, Acylation-Stimulating Protein (ASP). |