Thymidine kinase 1 (TK1) is a cytosolic enzyme involved in the salvage pathway of DNA synthesis, catalyzing the phosphorylation of thymidine to thymidine monophosphate during the S-phase of the cell cycle. Its expression is tightly regulated and peaks during cell proliferation, making TK1 a sensitive biomarker for cellular growth and turnover. In healthy individuals, serum levels of TK1 are typically low, but they increase in conditions associated with elevated cell proliferation, such as cancer or certain hematological disorders.
TK1 can be measured in serum or plasma using an enzyme-linked immunosorbent assay (ELISA), which provides a quantitative assessment of its concentration and activity. In research settings, TK1 ELISA is widely used to study cell proliferation, tumor biology, and the effects of anticancer therapies. Its levels can serve as an indicator of tumor growth, treatment response, or relapse in preclinical models and clinical trials.
Clinically, TK1 ELISA has potential applications in oncology as a non-invasive biomarker for cancer diagnosis, prognosis, and disease monitoring. Elevated TK1 levels have been associated with various malignancies, including leukemia, lymphoma, and solid tumors, reflecting increased tumor cell turnover. Additionally, serial measurement of TK1 can help track treatment efficacy and detect early relapse, supporting its role as a complementary tool alongside conventional imaging and laboratory tests.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 0.094 ng/mL |
| Dynamic Range | 0.078 ng/mL – 5.0 ng/mL |
| Incubation Time | 2 hours 30 minutes |
| Sample Type | serum/plasma |
| Storage | 2-8°C |
| Alternative Names | Thymidine kinase 1, Cytosolic thymidine kinase, and TK-1. |