Cellular senescence–associated secretory phenotype (CLS) markers, often measured using ELISA, reflect the presence and activity of senescent cells in tissues. Senescent cells are metabolically active but permanently growth-arrested, and they secrete a variety of inflammatory cytokines, chemokines, growth factors, and proteases collectively termed the senescence-associated secretory phenotype (SASP). These secreted factors contribute to tissue remodeling, chronic inflammation, aging, and the progression of age-related diseases. Measuring CLS biomarkers provides insights into cellular stress responses, tissue dysfunction, and the systemic effects of senescent cell accumulation.
In research, CLS ELISAs are used to quantify specific SASP components in cell culture supernatants, serum, or plasma, allowing scientists to study mechanisms of aging, inflammation, cancer, and tissue repair. They help evaluate the role of senescent cells in disease models, assess the impact of interventions such as senolytic drugs, and investigate how cellular senescence contributes to chronic pathological processes.
Clinically, CLS biomarker measurement can provide a window into age-related pathologies and chronic inflammatory conditions. Elevated levels of SASP factors detected by ELISA may indicate increased senescent cell burden, which is relevant in cardiovascular disease, fibrosis, and certain cancers. These assays can potentially aid in monitoring disease progression, evaluating therapeutic efficacy of senescence-targeted treatments, and guiding personalized strategies aimed at reducing the detrimental effects of senescent cell accumulation.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 0.094 ng/mL |
| Dynamic Range | 0.3125 -20 ng/mL |
| Incubation Time | 2 hours 50 minutes |
| Sample Type | Tissue Culture Fluids |
| Storage | 2-8°C |
| Alternative Names | Capillary Leak Syndrome, Vascular Leak Syndrome, and Systemic Capillary Leak Syndrome. |