Canine (Dog) KIM-1 ELISA Kit

Canine Kidney Injury Molecule-1 (KIM-1) is a type I transmembrane glycoprotein that is minimally expressed in healthy kidneys but is rapidly upregulated in renal proximal tubular epithelial cells following kidney injury. It serves as a sensitive and early biomarker of renal tubular damage, particularly in response to ischemic or nephrotoxic insults. KIM-1 is shed into the urine and can also be detected in serum, reflecting the degree of tubular injury and ongoing renal stress. Its expression correlates with the severity of kidney damage, making it a valuable indicator of acute kidney injury (AKI) before significant changes in traditional markers like serum creatinine or blood urea nitrogen occur.

The canine KIM-1 ELISA (enzyme-linked immunosorbent assay) enables precise quantification of KIM-1 levels in serum or urine. In research settings, it is widely used to study the mechanisms of renal injury, nephrotoxicity from pharmaceuticals, or the progression of kidney diseases in preclinical models. Researchers can use KIM-1 measurements to evaluate the protective effects of experimental therapies, understand pathophysiology of acute and chronic kidney injury, and develop novel interventions to prevent renal damage in dogs.

In clinical settings, KIM-1 ELISA is applied as an early diagnostic tool for detecting kidney injury in dogs, particularly in cases of toxin exposure, ischemia, or drug-induced nephropathy. It allows veterinarians to identify renal injury before conventional markers indicate significant dysfunction, enabling timely interventions that can improve outcomes. Additionally, monitoring KIM-1 levels can help track disease progression, assess treatment efficacy, and support prognostic evaluations in canine patients with kidney disease.

This product is manufactured in USA by Eagle Biosciences.