Canine Cystatin C is a low molecular weight protein produced by all nucleated cells and freely filtered by the glomeruli in the kidneys. It is a cysteine protease inhibitor that plays a role in regulating proteolytic activity in tissues. Because it is produced at a relatively constant rate and not significantly affected by muscle mass, diet, or inflammatory conditions, cystatin C has emerged as a reliable endogenous biomarker for assessing glomerular filtration rate (GFR) and overall kidney function in dogs. Elevated levels of cystatin C in serum or plasma typically indicate impaired renal function, even in early stages of kidney disease.
The Canine Cystatin C ELISA allows for sensitive and quantitative measurement of cystatin C concentrations in canine serum or plasma. In research settings, this assay is used to study renal physiology, evaluate kidney injury models, and investigate the effects of pharmacological interventions on renal function. It also provides a tool for exploring the relationship between cystatin C and systemic diseases that may impact renal health, such as hypertension, diabetes, or chronic inflammatory conditions in dogs.
In clinical practice, measuring canine cystatin C provides veterinarians with a more accurate assessment of kidney function compared to traditional markers like creatinine, particularly in early or mild renal impairment. It is valuable for diagnosing acute kidney injury, monitoring chronic kidney disease progression, and evaluating response to therapeutic interventions. The assay can also aid in screening at-risk canine populations, allowing earlier detection and management of renal dysfunction to improve long-term outcomes.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Dynamic Range | 0.07 ng/mL – 4 ng/mL |
| Incubation Time | 1 hour 50 minutes |
| Sample Type | Plasma, Serum, Urine |
| Storage | 2-8°C |
| Alternative Names | Gamma-trace, post-gamma-globulin, and cystatin-3. |