Serum Amyloid A (SAA) is a family of acute-phase apolipoproteins predominantly produced by the liver in response to inflammatory stimuli, infection, or tissue injury. In mice, as in humans, SAA levels can increase dramatically—up to 1000-fold—during the acute-phase response, making it an extremely sensitive biomarker of systemic inflammation and immune activation. SAA also plays functional roles in cholesterol transport, immune cell recruitment, and modulation of inflammatory signaling pathways.
In research settings, mouse SAA is commonly used to study acute and chronic inflammation, infection, metabolic disorders, and autoimmune diseases. It serves as a biomarker for monitoring disease progression, inflammatory responses, and therapeutic efficacy in experimental models. SAA measurements are particularly useful in studies of atherosclerosis, obesity-related inflammation, and chronic inflammatory conditions, where it reflects systemic inflammatory burden and metabolic dysregulation.
In clinical and translational contexts, measuring SAA in mouse models allows researchers to simulate human conditions such as sepsis, autoimmune disease, and chronic inflammatory disorders. Elevated SAA levels provide insight into disease severity, tissue injury, and response to treatments, making it a critical biomarker for evaluating anti-inflammatory or immunomodulatory therapies. Its rapid and robust response to inflammation makes SAA a valuable complement to other acute-phase proteins, bridging preclinical studies to potential human clinical applications.
This product is manufactured in USA by Eagle Biosciences.