C-Reactive Protein (CRP) is an acute-phase protein primarily synthesized by the liver in response to inflammatory stimuli, including infection, tissue injury, and cytokine signaling (especially IL-6). In mice, as in humans, CRP levels rise rapidly during systemic inflammation, making it a sensitive biomarker for monitoring the onset and intensity of inflammatory responses. It plays a role in innate immunity, promoting opsonization, complement activation, and clearance of apoptotic cells and pathogens.
In research settings, mouse CRP is widely used to study immune responses, inflammation, infection, and tissue injury. Researchers measure CRP to monitor acute-phase responses, disease progression, or treatment efficacy in models of sepsis, autoimmune disease, cardiovascular disorders, and metabolic inflammation. CRP is also used in studies evaluating anti-inflammatory drugs, vaccines, or immunomodulatory therapies, as changes in its levels reflect systemic inflammatory status.
In clinical and translational contexts, assessing mouse CRP serves as a preclinical analog for human inflammatory conditions. Elevated CRP levels in mouse models provide insight into disease severity, prognosis, and therapeutic efficacy for conditions like atherosclerosis, infection, and chronic inflammatory disorders. Monitoring CRP alongside other biomarkers enables comprehensive evaluation of immune and inflammatory pathways, supporting translational research that bridges preclinical findings to human clinical applications.
This product is manufactured in USA by Eagle Biosciences.