Plasminogen is a circulating glycoprotein synthesized primarily by the liver, which serves as the inactive precursor of plasmin, a key serine protease in the fibrinolytic system. In mice, as in humans, plasminogen plays a central role in breaking down fibrin clots, remodeling the extracellular matrix, and regulating tissue repair and inflammation. Measurement of plasminogen provides insight into coagulation, fibrinolysis, and proteolytic balance, making it a valuable biomarker in hemostasis and thrombotic research.
In research settings, mouse plasminogen is widely used to study thrombosis, fibrinolysis, wound healing, and cardiovascular diseases. It serves as a biomarker to evaluate the efficiency of the fibrinolytic system, the risk of pathological clot formation, or the impact of therapeutic interventions such as plasminogen activators or anticoagulants. Additionally, plasminogen studies are used to investigate inflammatory processes, tumor invasion, and tissue remodeling, as plasmin-mediated proteolysis influences cellular migration and extracellular matrix degradation.
In clinical and translational contexts, monitoring plasminogen in mouse models allows researchers to simulate human conditions such as plasminogen deficiency, thrombotic disorders, and impaired wound healing. Quantitative and functional assays provide insights into coagulation status, fibrinolytic activity, and therapeutic efficacy, supporting preclinical evaluation of drugs targeting the fibrinolytic or hemostatic systems. This makes mouse plasminogen a critical biomarker for bridging basic research to clinical applications in cardiovascular and hematologic diseases.
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