Calretinin is a calcium-binding protein belonging to the EF-hand family, expressed predominantly in specific subsets of neurons in the central and peripheral nervous system. It plays a critical role in calcium signaling, neuronal excitability, and synaptic plasticity. Because of its restricted and cell-specific expression, calretinin serves as a valuable biomarker for identifying certain neuronal populations, particularly interneurons in the cerebral cortex, cerebellum, and hippocampus. It is also used to study neural development, neuroprotection, and calcium-mediated signaling pathways.
In research, calretinin is employed as a marker for studying neuronal differentiation, circuitry, and function. Its expression is used to map specific interneuron populations, examine neurodevelopmental processes, and investigate calcium-dependent mechanisms in neuronal signaling. Additionally, calretinin is applied in models of neurodegenerative diseases to assess changes in neuronal subpopulations and calcium regulation. Researchers also use calretinin immunostaining to characterize neuronal networks in both healthy and disease states, providing insights into brain organization and pathology.
Clinically, calretinin serves as a diagnostic biomarker in pathology, particularly in identifying certain tumors such as mesothelioma and some neuroendocrine neoplasms. Its expression helps differentiate tumor types in histological analyses and can guide prognosis and treatment decisions. Overall, calretinin bridges basic neuroscience research with clinical diagnostics, offering a marker for both specific neuronal populations and disease-associated cell types.
This product is manufactured in Germany by DLD Diagnostika.
| Size | 1 x 96 Well |
| Sensitivity | 0.05 ng/mL |
| Dynamic Range | 0.25- 4.0 ng/mL |
| Incubation Time | 4 hours 30 minutes |
| Sample Type | EDTA Plasma, Serum |
| Storage | 2-8°C |
| Alternative Names | 29 kDa calbindin, CALB2, Calbindin-2 |
