Growth hormone-binding protein (GHBP) is a circulating protein that binds to growth hormone (GH) in the bloodstream, modulating its bioavailability and activity. GHBP is derived from the extracellular domain of the growth hormone receptor (GHR) through proteolytic cleavage or alternative splicing. By binding GH, GHBP prolongs the hormone’s half-life, regulates its interaction with receptors, and influences downstream signaling pathways such as the production of insulin-like growth factor-1 (IGF-1). As a biomarker, GHBP reflects GH receptor status, GH signaling capacity, and overall endocrine regulation.
In research, GHBP is used to study growth hormone physiology, receptor dynamics, and endocrine regulation in both animal models and humans. Measuring GHBP levels provides insights into GH bioavailability, receptor expression, and alterations in GH signaling due to genetic modifications, disease states, or pharmacological interventions. Researchers often examine GHBP alongside GH and IGF-1 to understand growth regulation, metabolic disorders, or endocrine feedback mechanisms.
Clinically, GHBP serves as a biomarker for growth disorders, GH resistance, and pituitary or liver dysfunction. Abnormal GHBP levels can indicate impaired GH receptor activity, GH insensitivity, or changes in GH metabolism. Monitoring GHBP can aid in the diagnosis of growth hormone deficiencies, GH receptor mutations, and therapeutic response to GH treatment, bridging fundamental research on GH signaling with translational and clinical endocrinology
This product is manufactured in by Mediagnost.
| Size | 1 x 96 Well |
| Sensitivity | 0.008 ng/mL |
| Dynamic Range | 0.05 – 4ng/mL, |
| Incubation Time | 3 hours |
| Sample Type | Serum, Plasma |
| Alternative Names | growth hormone-binding protein or GH-binding protein |
