Metanephrine is a metabolite of catecholamines, specifically epinephrine (adrenaline), formed through the action of catechol-O-methyltransferase (COMT). It is excreted in urine and present in plasma, serving as a stable biomarker for catecholamine metabolism and sympathetic nervous system activity. Because metanephrine reflects both basal and stress-induced catecholamine turnover, it is particularly useful for assessing conditions involving excessive catecholamine production, such as pheochromocytoma and paraganglioma. Sensitive assays like high-performance liquid chromatography (HPLC) with electrochemical detection or mass spectrometry are used to measure metanephrine levels accurately.
In research, metanephrine is used to study catecholamine physiology, stress responses, and the effects of pharmacological interventions on adrenergic signaling. Measuring metanephrine allows investigators to evaluate sympathetic activity under experimental conditions, assess drug effects on catecholamine metabolism, and explore the pathophysiology of hypertension, cardiovascular disorders, and stress-related diseases in both animal models and human studies.
This product is manufactured in Germany by LDN.
| Size | 1 x 96 Well |
| Sensitivity | 14.9 pg/mL |
| Dynamic Range | 36 – 3 600 pg/mL |
| Incubation Time | 5 hours 30 minutes |
| Sample Type | Plasma |
| Storage | 2-8°C |
| Alternative Names | O-methylated norepinephrine, normetadrenaline derivative, or 4-hydroxy-3-methoxymandelic acid amine. |
