Immunoglobulin M (IgM) is one of the five major classes of antibodies in dogs and serves as a critical component of the innate immune response. It is the first antibody isotype produced by B lymphocytes upon exposure to a novel antigen and is typically expressed as a pentameric molecule, allowing for high avidity binding despite relatively low affinity at individual binding sites. In canine immunology, IgM plays a key role in the early stages of infection, promoting complement activation, agglutination of pathogens, and opsonization, thereby facilitating pathogen clearance before class-switch recombination leads to IgG production.
In research settings, canine IgM serves as an important biomarker for studying immune responses to infection, vaccination, or autoimmune disorders. Measuring IgM levels can help differentiate between primary and secondary immune responses, as elevated IgM titers often indicate recent or acute exposure to a pathogen. It is also valuable in immunotoxicology and vaccine efficacy studies, where early humoral responses are used to assess immunocompetence and vaccine-induced protection.
Clinically, detection of canine IgM is used in diagnostic serology to identify acute infections caused by agents such as Canine distemper virus or Leptospira species. IgM assays—commonly enzyme-linked immunosorbent assays (ELISA) or immunofluorescence tests—aid veterinarians in distinguishing recent infections from past exposure or vaccination. Additionally, aberrant IgM levels can signal immune-mediated diseases or monoclonal gammopathies, making it a useful diagnostic and prognostic marker in veterinary medicine.
This product is manufactured in USA by Eagle Biosciences.
| Size | 1 x 96 Well |
| Sensitivity | 4.756 ng/mL |
| Dynamic Range | 25 ng/mL – 800 ng/mL |
| Incubation Time | 1 hour 10 minutes |
| Sample Type | Serum, plasma |
| Storage | 2-8°C |
| Alternative Names | IgM, μ-chain immunoglobulin, macroglobulin, and pentameric immunoglobulin. |