Myeloperoxidase (MPO) ELISA Kit

Myeloperoxidase (MPO) is a heme-containing enzyme predominantly expressed in neutrophils and, to a lesser extent, in monocytes. It plays a central role in the innate immune response by catalyzing the conversion of hydrogen peroxide and chloride ions into hypochlorous acid (HOCl), a potent antimicrobial oxidant. This reaction contributes to microbial killing but can also cause collateral oxidative damage to host tissues. Structurally, MPO is a dimeric glycoprotein with a molecular weight of approximately 150 kDa, and its distinctive green color arises from its heme prosthetic group. Beyond its enzymatic activity, MPO influences inflammation by modulating cytokine production, lipid oxidation, and nitric oxide metabolism.

In research settings, MPO is widely used as a biomarker of oxidative stress and inflammation. Elevated MPO activity or concentration serves as an indicator of neutrophil activation and has been extensively studied in diseases such as atherosclerosis, rheumatoid arthritis, and neurodegenerative disorders. Quantification of MPO levels in plasma, serum, or tissue samples helps elucidate pathophysiological mechanisms linking inflammation and oxidative damage.

Clinically, MPO has gained traction as a diagnostic and prognostic biomarker, particularly in cardiovascular medicine. Elevated plasma MPO levels have been associated with endothelial dysfunction, plaque instability, and an increased risk of major adverse cardiac events, even in patients with normal troponin levels. As such, MPO testing is being explored for early detection of cardiovascular risk and for monitoring therapeutic responses in anti-inflammatory or antioxidant interventions. Its dual role as both a mediator and a marker of inflammation makes MPO a valuable target for translational studies bridging basic oxidative biology and clinical diagnostics.

This product is manufactured in USA by Eagle Biosciences.